Background: Holistic health care is a crucial part of nursing care, particularly for oncology patients. Objectives: This study aimed to assess the satisfaction of oncology patients with the holistic care approach rendered by the oncology nurses at King Abdullah Medical City in Mecca, Saudi Arabia. Patients and methods: A descriptive quantitative research design was used among 96 oncology patients, who were asked to record their responses through an electronic survey instrument using randomized nonprobability convenient sampling technique. Results: Based on the results of the study relating to the four aspects of holistic care approach namely, physical, emotional, social and spiritual responses on patients' satisfaction were measured ranging from very satisfied to satisfied which meant that the selected aspects to measure holistic care approach on patients' satisfaction were found to be viable and important in their care and management. When these four aspects on holistic care approach grouped with the demographic variables, specifically the social and spiritual aspects, when grouped with age showed significant differences with a p-value of 0.001, which meant that with age, perceptions with care satisfaction significantly varied in terms of social and spiritual aspects. Conclusion:The entire study set out to determine cancer patients' satisfaction with the holistic care approach they received from their oncology nurses during their treatment and hospitalization at King Abdullah Medical City. In addition, the study identified the demographic profile of respondents and the effect of these demographic differences on patients' satisfaction levels.