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266823

Glucose-Lowering Drugs and Fracture Risk among Diabetics: Review Article

Article

Last updated: 03 Jan 2025

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Abstract

Background: Diabetic patients have an increased risk of bone fractures. Patients with type 1 DM are seven times more likely to suffer a fracture than those without DM, whereas those with type 2 DM are 1.3 times more likely to do so. Patients with T2DM have an increased risk for fractures, despite having a normal to increased bone mineral density, suggesting that other factors besides bone quantity must account for increased bone fragility. Objective: The aim of the current work was to assess fracture risk among diabetics who use glucose-lowering drugs. Methods: Fracture Risk, Glucose-Lowering Drugs, and diabetics were all looked for in PubMed, Google scholar, and ScienceDirect. References from relevant literature were also evaluated by the authors, but only the most recent or complete study from February 2016 to August 2022 was included. Due to the lack of sources for translation, documents in languages other than English have been ruled out. Papers that did not fall under the purview of major scientific investigations, such as unpublished manuscripts, oral presentations, conference abstracts, and dissertations, were omitted. Conclusion: Some of the newer glucose-lowering therapies for type 2 diabetes have been shown to improve renal and cardiovascular outcomes. However, treatments aimed at reducing glucose levels may potentially influence fractures risks.  

DOI

10.21608/ejhm.2022.266823

Keywords

fracture risk, Glucose-Lowering Drugs, diabetics

Authors

First Name

Nema Abd El-Wanees

Last Name

Abd El-Shafy

MiddleName

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Affiliation

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Email

nonamobark71@gmail.com

City

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Orcid

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First Name

Hamed Abd El-Aziz

Last Name

Deraz

MiddleName

-

Affiliation

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Email

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City

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Orcid

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First Name

Atef Goda

Last Name

Hussin

MiddleName

-

Affiliation

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Email

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City

-

Orcid

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First Name

Mostafa Mohamed

Last Name

Assy

MiddleName

-

Affiliation

-

Email

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City

-

Orcid

-

Volume

89

Article Issue

1

Related Issue

36332

Issue Date

2022-10-01

Receive Date

2022-10-23

Publish Date

2022-10-01

Page Start

5,949

Page End

5,954

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_266823.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=266823

Order

285

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Glucose-Lowering Drugs and Fracture Risk among Diabetics: Review Article

Details

Type

Article

Created At

22 Jan 2023