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266058

Evaluation of TP53 Gene Mutation in Chronic Lymphocytic Leukemia Patients

Article

Last updated: 03 Jan 2025

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Abstract

Background: In chronic lymphocytic leukemia (CLL) disease, B cell heterogeneity and enhanced cellular proliferation play major pathogenic roles. TP53 abnormalities namely, both 17p chromosome deletion (del 17 p) and TP53mutation are considered gold standards for the clinical course of CLL and provide a better prognostic risk stratification. Objectives: This was aimed to investigate TP53 mutations in patients with CLL and to assess their impact effect on the clinical course and hematological characteristics of these patients. Patients and methods: Forty newly diagnosed CLL adult patients were selected and subjected to full history taking, clinical examination, peripheral blood & bone marrow examination, and immunophenotyping in addition to TP53 mutation by real-time PCR. Results: TP53 gene mutation was positive in 20% of CLL cases, and this mutation was significantly associated with hepatosplenomegaly, lymphadenopathy, short LDT (<12 months), CD38 expression, high-grade staging, and poor response to therapy. Conclusion: One of the most potent prognostic markers required to direct treatment decisions for CLL is the TP53 mutations, which were linked to rapid disease progression and poor outcomes.  

DOI

10.21608/ejhm.2022.266058

Keywords

Chronic lymphocytic leukemia, 17p deletion, TP53

Authors

First Name

Olfat M.

Last Name

Hendy

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First Name

Amal Abd ELHameed

Last Name

Mohamed

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First Name

Yasmin Nabil

Last Name

Elsakhawy

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First Name

Asmaa Said

Last Name

Atta

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Email

asmaaatta8@gmail.com

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First Name

Karema Abd Alhadi

Last Name

Diab

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Volume

89

Article Issue

1

Related Issue

36332

Issue Date

2022-10-01

Receive Date

2022-10-18

Publish Date

2022-10-01

Page Start

5,807

Page End

5,812

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_266058.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=266058

Order

264

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Evaluation of TP53 Gene Mutation in Chronic Lymphocytic Leukemia Patients

Details

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Article

Created At

22 Jan 2023