Background: The use of endoscopy is crucial in the treatment of bleeding from peptic ulcers. Objective: To evaluate the clinical, laboratory, and endoscopic findings related to poor prognosis and to analyze the outcomes related to the treatment of peptic ulcer bleeding with different methods of endoscopic therapy. Patients and Methods: Thirty patients who underwent endoscopic treatment and were diagnosed with peptic ulcer bleeding at Zagazig University Hospitals (Intensive Care Units, Internal Medicine Departments, and Upper Gastrointestinal Endoscopy Units) participated in our prospective observational cohort study stratified as follows: adrenalin injection, argon plasma coagulation (APC), and adrenalin injection followed by argon plasma coagulation. Results: Patients treated with adrenaline injection modality had a higher percentage of rebleeding 71.4%, more red blood cell transfusion units with a median of 4 units, more hospital stay lengths with a median of 8.5 days compared with argon plasma coagulation and combined (adrenalin plus APC therapy) as less rebleeding were observed (40% and 0%) respectively, and fewer units of red blood cell transfusion (2% and 2%) respectively. Hospital stay median was 3.5 days in APC and 4 days in combined therapy. According to univariate logistic regression, nonsteroidal anti‐inflammatory drugs (NSAIDs) intake, large ulcer size, and high GBS were predictive factors of post-endoscopic rebleeding. Conclusion: Combining endoscopic adrenaline injection with argon plasma coagulation is more effective than either method alone in stopping bleeding from peptic ulcers and identifying risk factors may help in improving the prognosis of peptic ulcer bleeding.