Background: There is a tight association between preeclampsia and infection with H. pylori explained by in vitro studies. Objective: To evaluate the relationship between maternal infection with Helicobacter pylori and the occurrence of preeclampsia (PE) and the perinatal outcome. Subjects and Methods: Ninety-two pregnant women were included in this comparative observational study. Serum Immunoassay for H. Pylori IgG seropositivity was done for all patients. Results: The preeclamptic group shows statistically significant higher values of liver transaminase enzymes, total Bilirubin and decreased S. alb. These findings donate that liver is significantly affected in preeclampsia. There is statistically significant association between maternal infection with H. pylori and the increased incidence of intrauterine fetal death (IUFD), the need for neonatal intensive care unit (NICU) admission. And also, increased severity of preeclampsia and the occurrence of hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome. But the association with eclampsia was insignificant. Conclusion: There is association between PE and infection with H. pylori as H. pylori sero-positivity is higher among women with preeclampsia and increased perinatal feto-maternal complications among patient with H. pylori infection.