Background: After femoral artery catheterization, pseudoaneurysms are linked with considerable morbidity. Recently, percutaneous ultrasound-guided thrombin injection has become a possible first-line therapy. Objectives: This study aimed to compare the efficacy and safety of ultrasound-guided compression repair vs ultrasound-guided thrombin injection in treating post-catheterization femoral artery pseudoaneurysms were compared. Methods: One hundred patients with femoral pseudoaneurysms were randomised to receive either an ultrasound-guided compression or ultrasound-guided thrombin injection in this interventional study. Results: Success rates for ultrasound-guided thrombin injection were one hundred percent, whereas those for ultrasound-guided compression repair were only eighty percent, perhaps because of anticoagulant medication, hypertension, and aneurysms greater than six centimeters in size. Nevertheless, neither of these elements had an impact on how well thrombin injections worked. Conclusion: The success rate of ultrasound-guided thrombin administration is quite high and is simple procedure that were accepted and tolerated well by the patients.