Background: Modern dentistry aims to treat caries as little invasively as possible while preserving the tooth. To do this, use the tooth's ability to remineralize early caries lesions that aren't cavitated. Changing oral environment, can do this and tilt the scales in favor of remineralization rather than demineralization. Objective: To examine ability of two commercially toothpastes; one containing NovaMin and other containing HAP-NPs to remineralize artificially depleted enamel surfaces on baby teeth. Vickers microhardness tester used to measure surface microhardness. Surface roughness using SJ-210 surface roughness tester. In comparison to fluoridated toothpaste. Materials and Methods: Primary anterior teeth from 87removed individuals were allocated into three groups at random (n=29). Group A toothpastes include (NovaMin), Group B toothpastes include NHA, and Group C toothpastes contain fluoride. Before teeth were immersed in a demineralizing solution for 96hours, the baseline surface microhardness (SMH) and surface roughness were assessed using the vickers microhardness tester and the SJ-210 surface roughness tester, respectively. Demineralized sample SMH and roughness were measured after 10days of pH cycling. Results: Mean SMH was the highest value in NovaMin group (216.35±11.13) followed by fluoride (205.19±33.48), while the lowest value was found in Nano-hydroxyapatite group (203.67±14.14). Mean surface roughness was the highest value in fluoride group (0.98±0.27) followed by NovaMin (0.89±0.21), while the lowest value was found in Nano-hydroxyapatite group (0.88±0.21). Conclusion: NovaMin or Nano-hydroxyapatite are effective as fluoride in preventing the demineralization of enamel and promoting remineralization. For remineralizing caries-like lesions of primary anterior teeth; NovaMin and Nano-hydroxyapatite toothpastes are efficient.