264528

Clinicopathological Study and Management of Malignant Ovarian Tumors in Children and Adolescents, A Three-Years Study

Article

Last updated: 03 Jan 2025

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Abstract

Background: Ovarian tumors true incidence in young females is not known. Objective: To review the incidence of ovarian tumors in children and adolescents and their clinical presentation in these patients in Aswan city and district as representative of Egypt. We also characterized the pathological features of these ovarian tumors and tailor the best management of these tumors in young females(less than 18 years old). Patients and Methods: Thirty-six malignant ovarian tumors in females <18 years were followed in Surgery Department, Aswan University hospital. Different aspects were analyzed regarding clinicopathological data, investigations and treatment. Follow up by clinical examination, CT scan and laboratory profile was done every 3 months in the first year, then every 6 months in the second year and then yearly. The follow up period for each case was calculated from end of the treatment to the last follow up visit. Results: Thirty-six young female patients with malignant ovarian tumors were recorded, which represented 18% of total pediatric malignancy throughout the 3 years of the study. All patients underwent primary surgical resection through laparotomy. Unilateral salpingo-oophrectomy (USO) was performed. AFP was the commonest elevated marker in 6 cases and CA125 in 4 cases. The most common symptom was abdominal mass in 14 cases and most common tumor was yolk sac tumor 14 cases. All cases received chemotherapy adjuvantly except the four cases stage 1. However, due to progression and recurrence, six cases required further chemotherapy lines. Conclusion: Yolk sac tumor and dysgerminoma are the commonest pediatric malignant ovarian tumors in this study. Multimodality treatment is essential. Fertility preservation should be respected. The advanced stages have the highest mortality.  

DOI

10.21608/ejhm.2022.264528

Keywords

Ovarian tumors, Children And Adolescents

Authors

First Name

Ibrahim

Last Name

Elzayat

MiddleName

Mohamed

Affiliation

Lecturer of General Surgery, Faculty of Medicine - Aswan University

Email

ibrahimelzayat@med.aswu.edu.eg

City

aswan

Orcid

-

First Name

Osama Abdullah

Last Name

Abdulraheem

MiddleName

-

Affiliation

-

Email

-

City

-

Orcid

-

First Name

Hany

Last Name

Soliman

MiddleName

-

Affiliation

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Email

-

City

-

Orcid

-

First Name

Sherif El Prince

Last Name

Sayed

MiddleName

-

Affiliation

-

Email

-

City

-

Orcid

-

Volume

89

Article Issue

1

Related Issue

36332

Issue Date

2022-10-01

Receive Date

2022-10-08

Publish Date

2022-10-01

Page Start

5,464

Page End

5,468

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_264528.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=264528

Order

208

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Clinicopathological Study and Management of Malignant Ovarian Tumors in Children and Adolescents, A Three-Years Study

Details

Type

Article

Created At

22 Jan 2023