Background: Three decades have passed since the creation of percutaneous nephrolithotomy (PNL), the medical name for the non-invasive removal of kidney stones. It has been documented that a percutaneous track was created to later aid in the removal of an intrarenal stone. When it comes to the fundamental surgical procedure, individual urologists may have their own preferences and little alterations. For a procedure to be considered the gold standard, it must be well-documented, risk-free, consistently effective, easy to teach and learn, and consistently reproducible. Objective: Assessment of percutaneous nephrolithotomy role in managing renal stones. Methods: Percutaneous nephrolithotomy, renal, and stones were all looked for in PubMed, Google scholar, and Science direct. References from relevant literature were also evaluated by the authors, but only the most recent or complete study from March 2010 to April 2021 was included. Due to the lack of sources for translation, documents in languages other than English have been ruled out. Papers that did not fall under the purview of major scientific investigations, such as unpublished manuscripts, oral presentations, conference abstracts, and dissertations, were omitted. Conclusion: Stones smaller than 2 centimeters in diameter may be candidates for percutaneous nephrolithotomy (PCNL), the treatment of choice for larger stones.