Background: Multimodal analgesia refers to the use of several medications, often started preoperatively that target multiple loci along the pain pathway. Multimodal therapy attempts to modify the inflammatory response to surgery or decrease the immediate or long-term consequences of tissue injury and the pain that ensues. Such an approach may theoretically improve pain control, limit the dose and adverse effects of any one drug, and reduce opioid requirements. In most practice, the combination of acetaminophen and nonsteroidal inflammatory drugs (NSAIDs) is the basis for multimodal postoperative analgesia for most patients who are without contraindications. However, while there are data suggesting efficacy of multimodal analgesic therapy in adults. Objective: Assessment of roles and benefits of perioperative multimodal analgesia. Methods: Multimodal, and analgesia were all looked for in PubMed, Google scholar, and Science direct. References from relevant literature were also evaluated by the authors, but only the most recent or complete study from January 2000 to May 2021 was included. Due to the lack of sources for translation, documents in languages other than English have been ruled out. Papers that did not fall under the purview of major scientific investigations, such as unpublished manuscripts, oral presentations, conference abstracts, and dissertations, were omitted. Conclusion: Combined use of multimodal opioid sparing analgesics such as Paracetamol, NSAIDs, Gabapentin, Dexmedetomidine, the clinical neurologic evaluation can be maintained while the patient receives the benefits of a scalp block for pain management and opioid reduction.