Background: As laparoscopic repair of groin hernia is gaining popularity; most surgeons argue over which mesh fixation techniques are the best. Objective: The present study was conducted to compare the outcomes of mesh fixation using fibrin glue versus tackers in laparoscopic transabdominal preperitoneal (TAPP) repair of inguinal hernia, with the ultimate goal of bettering the health and happiness of inguinal hernia patients. Subjects and Methods: This study included a total of 24 inguinal hernia patients chosen for laparoscopic transabdominal preperitoneal repair with mesh fixation by fibrin glue versus tackers, attending at General Surgery Department, Zagazig University Hospitals. Patients were randomly divided into 2 equally groups: Group (A) A fibrin glue was used to fix the mesh and Group (B) Using tackers, to fixed the mesh. Results: There was a statistically significant difference between the groups investigated in terms of operative time, with the fibrin glue group taking significantly longer than the tackers group. Within-day pain and length of hospital stay did not differ significantly between the groups. While return to daily activity was faster in fibrin glue groups. The cost of all cases of fibrin glue group was lower than that of tackers group. Conclusion: It could be concluded that mesh fixation by fibrin glue is better than tacker as mesh fixation with glue causes less post-operative pain and less analgesia is needed as well as low financial cost.