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260756

Neutral Protamine Hagedorn versus Glargine 100 International Units among Elderly Patients with Type 2 Diabetes Fasting Ramadan

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Last updated: 03 Jan 2025

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Abstract

Background: One of the main five pillars of Islam is Ramadan fasting. In Egypt, Muslims usually fast from 12 to 16 hours. Neutral Protamine Hagedorn (NPH) is cheaper basal insulin in comparison to Glargine U100, and has shorter duration of action. Main fear from insulin usage in elderly with type 2 diabetes mellitus (T2DM) in Ramadan is hypoglycaemia. Objective: The aim of the present study was to compare the safety and efficacy NPH versus Glargine U100 among elderly patients fasting Ramadan. Patients and methods: The study was conducted on 100 patients of both genders with T2DM aged 60 years and more. Comprehensive geriatric assessment was done. Weight, glycated haemoglobin (HbA1c) and creatinine (1 month before Ramadan and 2 months after Ramadan) were estimated. Moreover, numbers of documented hypoglycaemia and days of breaking fast were compared. Results: The mean age of the patients was 65.9 (SD 3.6) years among glargine group, and 66.2 (SD 3.7) years among NPH group, and 58 of the participants were females. There was significant difference in days to break fasting from hypoglycemia [3 days in NPH group versus 10 days in glargine group (P-value 0.03)]. No statistical difference regarding weight and creatinine before and after Ramadan among both groups. Conclusion: NPH could be a better option than Glargine U100 for elderly patients with T2DM willing to fast Ramadan, with less reported attacks of hypoglycaemia and lower cost.  

DOI

10.21608/ejhm.2022.260756

Keywords

Elderly, Type 2 diabetes mellitus, Ramadan fasting, NPH, Glargine U100

Authors

First Name

Hossam

Last Name

Ghazi

MiddleName

Arafa

Affiliation

Lecturer of Internal medicine Faculty of medicine Mansoura University

Email

hossamghazi7@gmail.com

City

Elmahalla Elkobra

Orcid

0000-0002-2595-0657

Volume

89

Article Issue

1

Related Issue

36332

Issue Date

2022-10-01

Receive Date

2022-09-22

Publish Date

2022-10-01

Page Start

4,865

Page End

4,869

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 89_Issue 1_Pages 4865-4869.pdf

PDF . 442.8kB

Link

https://ejhm.journals.ekb.eg/article_260756.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=260756

Order

115

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Neutral Protamine Hagedorn versus Glargine 100 International Units among Elderly Patients with Type 2 Diabetes Fasting Ramadan

Details

Type

Article

Created At

22 Jan 2023