Background: Preeclampsia is a major contributor of maternal and perinatal morbidity and mortality. The purpose of this study was to look at the predictive usefulness of placental growth factor (PLGF), maternal characteristics (MC), and uterine artery Doppler for preeclampsia in the first trimester. Patients and methods: A cross-sectional survey was conducted on 805 pregnant women between 11 + 0 and 13 + 6 weeks' gestation. A complete history and clinical examination were taken at the booking visit, a bilateral uterine artery Doppler study was estimated, and the mean pulse index (PI) was computed and recorded. A venous blood sample was drawn and centrifuged for 10 minutes at 3000 rpm to extract the serum, which was then frozen at 80 C for further examination for placental growth factor (PLGF). Results: PE developed in 54 (6.7%) cases; 11 (20.4%) early-onset and 43 (79.6%) late-onset. The following parameters were calculated: sensitivity, specificity, positive and negative value (PPV and NPV), and accuracy. The sensitivities for MC, PLGF and UADPI for prediction of early-onset preeclampsia were 27.3%, 54.5%, and 72.7%, respectively. The sensitivities for MC, PLGF and UADPI for prediction of late-onset preeclampsia were 14%, 55.8%, and 51.2%, respectively. The sensitivity for combination between the three factors used to predict PE were 85.7% for early-onset and 79.4% for late-onset preeclampsia, respectively. Conclusions: Effective screening for PE may be accomplished in the first trimester of pregnancy, at 11-14 weeks' gestation, by combining maternal features with the findings of uterine artery Doppler and placental growth factor to determine the risk of PE development.