Background: Functional capacity (defined as the ability of individuals to do their daily living activities) in hemodialysis patients is affected due to peripheral muscles and pulmonary function impairment. Objective: This study aimed to evaluate the effect of different types of deep breathing training on functional capacity and fatigue level in hemodialysis patients. Patients and methods: A total of 111 hemodialysis patients of both sexes with end stage renal disease (ESRD) participated in the study with age ranged from 55 to 65 years old. They were randomly recruited from Quesna Central Hospital from Dialysis Unit. They were assigned randomly into three groups (A, B & C). Group (A) consisted of 37 patients who received Diaphragmatic Breathing Exercise 3 sessions per week, 20 minutes for each session with 6 sets per each session, for 8 successive weeks. Group (B) consisted of 37 patients who received breathing training by incentive Spirometer Device 3 sessions per week, 20 minutes for each session with 6 sets per each session, for 8 successive weeks. Group (C) consisted of 37 patients who received their medical treatment and hemodialysis only. Results: A significant change in six-minute walk test (6MWT) and fatigue assessment scale (FAS) in the 3 groups post-training compared with that pre-training was observed. There was no discernible difference existed between the 3e post-training groups in terms of 6MWT. However, there was significant decrease in FAS of the group A and B post training compared with that of the group C. Conclusion: Different types of deep breathing training improve the functional capacity and the fatigue level in hemodialysis patients.