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259131

The Role of Hemoglobin A1c Level in Prediction of Adverse Obstetric and Neonatal Outcomes in Pregestational Diabetic Pregnancies

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Last updated: 03 Jan 2025

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Abstract

Background: An elevated HbA1c has been associated with a significantly increased risk of many adverse obstetric outcomes including congenital anomalies, spontaneous abortions, preeclampsia, and large for gestational age infants at birth. Objective: This study aimed to predict adverse obstetric and neonatal outcomes in pregestational diabetic pregnancies. Patients and method: The study included 72 pregnant diabetic women in the third trimester of pregnancy (28 weeks to 40 weeks) divided into two groups; Good glycemic control group (Hb A1c <6.5%) (n=30), and poor glycemic study group (HbA1c >6.5%) (n=42). Participants were followed up till delivery and maternal and perinatal outcomes were studied. All participants were subjected to careful history taking, through clinical and obstetric examination. The newborns were examined, and their conditions were assessed by pediatricians. Result: There was a statistically non-significant association between glycemic control of the studied patients and mode of delivery; Poor glycemic study group had 35 (83.3%) cesarean sections (CS) versus 20 (66.7%) CS in good glycemic control group. There was a statistically significant association between glycemic control of the studied patients and body mass index. There was a statistically significant association between glycemic control of the studied patients and parity which was significantly higher in those with high parity. There was a statistically non-significant association between glycemic control of the studied patients and their age, gravidity, history of abortion, IUFD or macrosomia. Conclusion: Antenatal HbA1c values are useful to predict adverse obstetric and neonatal outcomes, especially preterm delivery and hyperbilruinemia in pregnancies complicated by pregestational diabetes. Also, antenatal HbA1c values are useful for objective risk stratification of patients with pregestational diabetes.  

DOI

10.21608/ejhm.2022.259131

Keywords

Hemoglobin A1C, Pregnant diabetic, Women neonatal outcomes, cesarean section

Authors

First Name

Khuloud Mohamed Khalifa

Last Name

Elmaghirbi

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Email

khuloudmoh21@gmail.com

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First Name

Amr Kamel El-sayed

Last Name

El-fayomy

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Affiliation

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Orcid

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First Name

Hala Sherif

Last Name

El-Sayed

MiddleName

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Affiliation

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Email

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Orcid

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First Name

Ahmed Metwally

Last Name

El katawy

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Affiliation

-

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Volume

89

Article Issue

1

Related Issue

36332

Issue Date

2022-10-01

Receive Date

2022-09-12

Publish Date

2022-10-01

Page Start

4,645

Page End

4,651

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_259131.html

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https://ejhm.journals.ekb.eg/service?article_code=259131

Order

82

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

The Role of Hemoglobin A1c Level in Prediction of Adverse Obstetric and Neonatal Outcomes in Pregestational Diabetic Pregnancies

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Article

Created At

22 Jan 2023