Background: Polycystic Ovarian Syndrome(PCOS) is characterized by metabolic, endocrine, and genetic abnormalities, as well as the absence of ovulation and clinical and biochemical manifestations of hyperandrogenism. Menstrual irregularities, hirsutism, acne, alopecia, and infertility are all symptoms of PCOS. PCOS is a gynecological condition that affects women of reproductive age. Drugs like clomiphene citrate, tamoxifen, and metformin are used to treat PCOS in women. Alternative medications with fewer side effects and more relative treatment, such as plant-based drugs, especially estrogen-containing drugs, should be sought. The objective of the present study was to evaluate the effectiveness of date palm pollen in PCOS. Patients and methods: One-arm clinical trial was conducted at Alzahraa University Hospital over 2 years from 2018 to 2020; 50 women who met the Rotterdam criteria for PCOS were enrolled in the study, which included daily administration of 3 gm of date palm pollen (DPP) for three months, and followed up for sex hormones, follicle-stimulating hormone (FSH) luteinizing hormone (LH), estrogen, and progesterone after three months of treatment and growth of the follicles every month. Result: There was an improvement in sex hormone levels, with lower estrogen and LH levels and higher progesterone and FSH levels, and a cumulative effect on ovulation. Only 6% of the participated women became pregnant during the study period. Conclusion: Date palm pollencan be used for the management of women with infertility with PCOS.