Background: Assessment of Insulin Resistance (IR) as well as glucose intolerance are advised among Polycystic Ovary Syndrome (PCOS) cases. Objective: To study the rate of IR among infertile women with PCOS at Zagazig University Hospitals.  Subjects and Methods: the study was conducted on 60 infertile women with age from 18 to 35 years old as cross sectional trial, at Clinical Pathology Department and outpatient clinic of Obstetrics and Gynecology Department Zagazig University Hospitals with calculation the frequency of insulin resistant among infertile women with polycystic ovaries. Results: The prevalence of IR among the studied cases was 60%. body mass index (BMI), waist circumference (WC), and presence of hirsutism differed significantly between both studied groups. Testosterone levels and FBI were significantly higher among IR cases compared to non IR cases.  Conclusion: incidence of insulin resistance is around 60% in PCOS infertile cases. Clinically, the G/I ratio may be beneficial in identifying insulin-resistant PCOS women and choosing those most likely to benefit from therapy interventions that increase insulin sensitivity.