Background:  Isotretinoin is an essential medication for a variety of conditions and uses, including the treatment of severe acne and chemoprevention. Because of the rise in isotretinoin prescriptions, doctors need to be well-versed in the drug's potential side effects, toxicities, and management challenges. The manufacturer has responded to the most pressing problem, congenital abnormalities, by introducing new policies and programmes designed to reduce the likelihood of unplanned pregnancy. Depression in patients using isotretinoin is a new cause for alarm. While mucocutaneous and ocular side effects are the most common, effects on the neurological, musculoskeletal, gastrointestinal, pulmonary, and hematologic systems are also recorded, along with laboratory abnormalities. Additionally, precautions against toxicity, possible drug interactions, and further monitoring are recommended. Objective: Assessment of side effects of isotretinoin use in dermatology. Methods: Isotretinoin, dermatology, and side effects were all looked for in PubMed, Google scholar, and Science direct. References from relevant literature were also evaluated by the authors, but only the most recent or complete study from January 2001 to February 2022 was included. Due to the lack of sources for translation, documents in languages other than English have been ruled out. Papers that did not fall under the purview of major scientific investigations, such as unpublished manuscripts, oral presentations, conference abstracts, and dissertations, were omitted. Conclusion: Isotretinoin is a medicine used all over the world to treat various skin conditions in both sexes and people of all ages. Despite its widespread usage, however, isotretinoin is not without its share of negative side effects. To enhance clinical results and reduce the likelihood of adverse events, it is crucial to obtain thorough informed consent from patients and to counsel and follow them closely.