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256596

The Impact of IL-35, Bacterial Prostatitis in Development Male Infertility in Najaf Province Patients

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Last updated: 03 Jan 2025

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Abstract

Background: A case-control study examined the relationship between bacterial prostatitis and IL-35 blood levels in the emergence of male infertility. Objective: This study aimed to assess the role that bacterial prostatitis and IL-35 play in the progression of male infertility in patients from Najaf province. Patients and Procedures: 120 patients were seen at AL-Sadder Medical City, Al-Najaf province through the period from January to June, 2021. This number included sixty prostatitis-related infertile patients, 30 prostatitis-related fertile patients, and 30 infertile patients. 30 healthy fertile male subjects served as control group.All subjectsprovided blood and semen samples and three ml of the blood were placed in a gel tube to separate the serum used to calculate IL-35 level by ELISA. A loop of semen was collected to identify the bacterial culprits as well as semen liquefaction, volume, appearance, and fundamental sperm characteristics in the residual semen (density, motility, viability, and morphology). Results: Prostatitis patients had considerably lower serum concentrations of IL-35 than infertile patients did, according to the findings (P ). The concentration of IL-35, which is thought of as a biomarker for a progressive state, decreased with the severity of the disease. The findings showed that S. aureus and E. coli were the most frequent bacterial causes of prostatitis. Conclusion: The current study found a correlation between infertility and the infection with prostatitis condition, which is reflected in the body's immune response as a lower level of IL-35.  

DOI

10.21608/ejhm.2022.256596

Keywords

Il-35, Serum level, Infertility, prostatitis, men

Authors

First Name

Kais Khudhair

Last Name

Al-hadrawi

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Email

kaisalhadrawii@gmail.com

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First Name

Raid Talib

Last Name

ALGarawy

MiddleName

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City

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Orcid

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First Name

Mayyada F.

Last Name

Darweesh

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-

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Volume

89

Article Issue

1

Related Issue

36332

Issue Date

2022-10-01

Receive Date

2022-08-28

Publish Date

2022-10-01

Page Start

4,278

Page End

4,283

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_256596.html

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https://ejhm.journals.ekb.eg/service?article_code=256596

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22

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

The Impact of IL-35, Bacterial Prostatitis in Development Male Infertility in Najaf Province Patients

Details

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Article

Created At

22 Jan 2023