Background: As many as 200 million people around the world are affected with peripheral artery disease (PAD), a long-term atherosclerotic problem. The majority of individuals with PAD are asymptomatic, but those who do experience symptoms, such as limb claudication or complete tissue loss, should seek medical attention right away. PAD and its consequences are widespread because of the worldwide growth in the frequency of Type 2 Diabetes Mellitus (T2DM) and the ageing of the general population. Peripheral artery disease can be caused by a combination of vessel wall stiffness and T2DM. Fatty acid binding proteins (FABPs) have been related to the onset of insulin resistance and other manifestations of the metabolic syndrome, and it has been shown that FABPs play an important role in metabolic control. FABP has been linked to fatty acid absorption and chylomicron release in the gastrointestinal tract, according to studies. Objective: The present review aims to assess of possible role ofFABPs in T2DM and PAD. Method: FABPs, T2DM and PAD were all looked for in PubMed, Google scholar, and Science direct. References from relevant literature were also evaluated by the authors, but only the most recent or complete study from January 2000 to May 2021 was included. Due to the lack of sources for translation, documents in languages other than English have been ruled out. Papers that did not fall under the purview of major scientific investigations, such as unpublished manuscripts, oral presentations, conference abstracts, and dissertations, were omitted. Conclusion: High levels of some of FABPs in the blood have been linked to both the existence and severity of PAD.