Background: An anastomosis between the small and large intestines must be created after bowel resection. The best method for re-establishing continuity is extracorporeal anastomosis, although intracorporeal (IC) anastomosis is also an option that has been proven to be as secure and effective in a number of observational studies. Objective: This study aimed to standardize the most ideal technique of anastomosis after laparoscopic right hemicolectomy with the least chance for leakage and better quality of life for patient of cancer colon. Patients and Method: A prospective clinical trial study was conducted in the Onco-Surgery Unit, General Surgery Department, Faculty of Medicine, Zagazig University through the period from October 2021 to July 2022. The study included 18 patients with right side colon cancer for Laparoscopic right hemicolectomy. The patients were divided into two equal groups 9 cases for intracorporeal ileocolic anastomosis (Group A) and 9 cases for extracorporeal ileocolic anastomosis (Group B). Results: Our findings were mainly that EC anastomosis group had a significantly shorter operative time compared to group A (p value 0.004), and significantly longer postoperative hospital stay (p value 0.0001). In the current study, IC anastomosis had markedly lower complication rate 11.1% versus 88.9% in EC group (p value 0.0001). Conclusion: Intracorporeal (IC) anastomosis after laparoscopic hemicolectomy is time saving and less morbid technique compared to extracorporeal anastomosis.