Background: Angiomatoid Fibrous Histiocytoma (AFH) is a rare soft tissue tumor that occurs most often in children, teenagers and young adults. In clinical and radiographic terms, the lesion is easily mistaken for hematoma, soft tissue hemangioma or malignant fibrous histiocytoma. While the lesion is rare, because of the potential for local recurrence and metastasis, this lesion must be accounted for in the differential diagnosis of a soft tissue mass.
Objective: A case report of angiomatoid fibrous histiocytoma; the clinical, radiological and pathological outcomes.
Case Report: Our case report of a 30 years old female who presented with left knee soft tissue mass anterior to the patella, which was discomforting, painful mass. X-ray and MRI of the left knee showed a soft tissue mass in the adipose tissue not attached to the underlying musculature. Wide margin resection was done,
Result: Histopathology report findings were consistent with angiomatoid fibrous histiocytoma. CT staging done postoperatively with no sign of metastatic lesion. Follow up MRI left knee done showed no sign of recurrence.
Conclusion: Angiomatoid fibrous histiocytoma is a rare soft tissue tumor with intermediate malignant potential. Although non-specific, a mass with MRI characteristics, including cystic areas, a fibrous pseudocapsule and internal blood spots on the extremity of a child, adolescent or young adult, AFH must be considered as part of the differential diagnosis. A wide surgical excision with clear margins and post-excision follow-up is required.