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247128

Role of Serum Procalcitonin in Monitoring the Response to Treatment of Pediatric Bacterial Meningitis

Article

Last updated: 03 Jan 2025

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Abstract

Background: Early diagnosis and appropriate management are important to reduce the complications of acute bacterial meningitis (ABM). Serum procalcitonin (PCT) is one of the most sensitive and specific markers for identification of ABM. Objective: This study was done to evaluate serum PCT as a marker to confirm ABM especially after oral antibiotics intake or when cerebrospinal fluid (CSF) culture is negative and to assess its correlation with outcome of ABM in children. Methods: This is a prospective cohort study that included 38 children with suspected ABM who presented to Ain Shams University Children Hospital over a period of 6 months. The PCT levels were measured on admission and 72 hours (h) after treatment. Results: Sixteen cases received oral antibiotics before admission, out of which only 6 (38%) patients showed growth in CSF bacterial culture. All the 38 cases showed elevated levels of PCT on admission. There was a significant drop in the mean of PCT level after 72 h of treatment compared to level on admission (7.1±6.5 vs. 11.4±3.7, p=0.001) respectively. There was a significant difference in the mean of PCT level between cases with good versus poor outcome, on admission (7.2±2.8 vs. 13.2±4.4, p < 0.001) and 72 h after treatment (4.2±3.5 vs. 12.9±5.3, p < 0.001) respectively. Conclusion: Serum PCT levels were high in all patients with suspected ABM, including those who received oral antimicrobials for 1-3 days before admission. The decline in PCT levels after treatment was associated with favorable outcome in our cohort.

DOI

10.21608/ejhm.2022.247128

Keywords

Bacterial Meningitis, CSF, Pediatric, Procalcitonin

Authors

First Name

Maha

Last Name

Mohammed

MiddleName

Zakariya

Affiliation

Department of pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

mahazakariya@med.asu.edu.eg

City

Cairo

Orcid

0000-0002-6098-561X

First Name

Eman

Last Name

Elhaddad

MiddleName

-

Affiliation

-

Email

emanelhaddad7@gmail.com

City

-

Orcid

-

First Name

Rania

Last Name

Shatla

MiddleName

-

Affiliation

-

Email

raniashatla@yahoo.com

City

-

Orcid

-

Volume

88

Article Issue

1

Related Issue

33970

Issue Date

2022-07-01

Receive Date

2022-07-01

Publish Date

2022-07-01

Page Start

3,213

Page End

3,216

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 88_Issue 1_Pages 3213-3216.pdf

PDF . 520.1kB

Link

https://ejhm.journals.ekb.eg/article_247128.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=247128

Order

148

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Role of Serum Procalcitonin in Monitoring the Response to Treatment of Pediatric Bacterial Meningitis

Details

Type

Article

Created At

22 Jan 2023