Background: Distal radius and ulna fractures are the most common fracture in adults representing 44% of all fractures. Fragment-specific fixation can be a useful tool in treating distal radius fractures. 
Objective: The aim of the present study was to evaluate the results of treating intra-articular distal radius fractures with fragment-specific fixation to provide good functional outcome.
Patients and methods: This prospective study included 36 patients with distal radial fractures. They were admitted and operated in the Casualty Unit of the Orthopedic Department, Zagazig University Hospitals. The average time of follow up period of the cases was 9 months. Results: Age was distributed as 39.5 ± 9.17 years, male were 61.1% and dominant right were in 88.9%. Mayo score distribution at different time among studied group was significant increase from 6 weeks to 3 months and to 6 months. There was significant increase in range of motion distribution from 6 weeks & 3 months to 6 months. There was significant increase in grip strength distribution from 6 weeks & 3 months to 6 months. Overall complicated cases were 6 cases. Complicated cases were significantly associated with longer union time and significant delayed return to work. Conclusion: Fragment-specific fixation is a valuable technique for intra articular distal radius fractures in well planned and selected patients. As it achieves a high rate of union and good functional outcome on follow up and it allows excellent grip strength and range of motion of wrist joint.