Background: Human papilloma virus (HPV) causes viral warts, which affect around 10% of the population. HPV types 1, 2, and 57 are frequently implicated as etiological factors in the majority of cases. It's more difficult to diagnose and cure HPV 4 and 7 because of their rarity. It is possible to combine several treatments for viral warts because treatment might be time-consuming in some circumstances, even when various options are accessible. In spite of reports of successful systemic acitretin therapy for viral warts resistant to previous treatments, oral acitretin therapy has only been used in a limited number of cases. Objective: Assessment of role ofintralesional zinc sulphate 2% in the treatment of multiple recalcitrant warts. Methods: Warts, Zinc sulphate, Recalcitrant warts, and the Human Papillomavirus were all looked for in PubMed, Google scholar, and Science direct. References from relevant literature were also evaluated by the authors, but only the most recent or complete study from January 2000 to January 2022 was included. Due to the lack of sources for translation, documents in languages other than English have been ruled out. Papers that did not fall under the purview of major scientific investigations, such as unpublished manuscripts, oral presentations, conference abstracts, and dissertations, were omitted. Conclusion: Warts can also be cleared with intralesional 2 percent zinc sulphate. Children may benefit from using topical or oral zinc as an alternative to harsh manual treatments for warts.