Background: Intradialytic hypertension is an underrecognized complication in hemodialysis patients, increasing cardiovascular morbidity, mortality, and hospitalization. Objective: The aim of the current work was to detect the incidence of intradialytic hypertension in hemodialysis patients and to compare the effect of high flux versus low flux dialysis on intradialytic hypertension and adequacy of dialysis. Patients and Methods: The study was conducted on 200 patients on regular hemodialysis in Beheira governorate. The patients were divided into: Group 1 including 100 patients on hemodialysis with high flux dialyzers and Group 2 including100 patients on hemodialysis with low flux dialyzers. Results: The incidence of intradialytic hypertension in hemodialysis patients was 23.5 % at the start, 21% after one month and 13% after three months duration. There was a significant reduction in number of intradialytic hypertension patients after one month duration and after three months in both groups. Adequacy of dialysis in the form of Kt/V and urea reduction ratio showed highly significant improvement by the end of the study in the high flux group. Kidney function tests, serum parathyroid hormone levels and serum hemoglobin levels showed significant improvement at the end of the study in high flux group compared to low flux group. Conclusion: It could be concluded that the current study has not demonstrated a significant difference between both groups regarding the effect on intradialytic hypertension, but adequacy of dialysis in the form of Kt/V and urea reduction ratio improved significantly by the end our study in the high flux group.