Background: Among women, breast cancer is the most common kind of diagnosis, the main cause of cancer-related death, and the leading source of lost life years due to disability-adjusted for global mortality. Breast-conserving surgery or mastectomy is common in the treatment of the disease which was relied on for many years. Seroma is a common side effect after mastectomy. Some surgeons view it as a necessary evil that must be endured after surgery. Seroma formation following breast surgery can occur anywhere from 3% to 85% of the time. Objective: This review aims to give an overview of seroma formation after mastectomy surgeries and the possible treatment options. Methods: The databases were searched for articles published on 3 databases [PubMed -Google scholar-science direct] and Boolean operators (and, or, not) had been used such as [Post Mastectomy Seroma, Breast cancer surgery and Treatment for breast cancer] and in peer-reviewed articles between January 2009 and June 2021. Conclusion: Although post-mastectomy seroma occurs in the vast majority of individuals, tightening the flap after surgery may help avoid its development.