Background: One of the most important cardiovascular risk factors is essential hypertension, a disease that affects a large percentage of the population. Objective: The purpose of this study was to establish a probable relationship between IL-6 levels and both insulin resistance and essential hypertension. Methods: This is a case-control study. Ninety participants were involved: sixty essential hypertensive patients and thirty healthy control who were matched for age and gender. The fasting and two-hour postprandial plasma glucose, serum fasting insulin, HOMA-IR, and serum IL6 levels of all patients and control group were all examined. Results: In comparison to the control group, fasting insulin and the HOMA-IR values in the hypertension group were considerably higher. The median level of IL-6 in the hypertensive group (5.85 pg /ml) was substantially greater than in the control group (1.49 pg /ml). Overall fasting insulin, fasting blood glucose, and HOMA-IR showed positive correlation with IL-6, which is an indicator of insulin resistance. Conclusion: Screening of IL-6 may be an indicator of insulin resistance in hypertensive patient. Further research into the processes underlying these connections is required.