Background: decreased rates of gestation are detected in cases with uterine space irregularities. The correction of these irregularities was accompanying with better rates of gestation. Diagnostic hysteroscopy could be accomplished with negligeable distress and higher sensitivity and specificity in assessment of the uterine space. Objective: This study aimedto assess the role of hysteroscopy in diagnosing the abnormalities of the uterine space among females having secondary infertility. Subjects and methods: This work was conducted on138 cases having secondary infertility with no suspected uterine defect at the Gynecological Outpatient Clinic in Al-Hussein University Hospital, Al-Azhar University. Result: The majority of the patients had hysteroscopy as part of their infertility treatment (77.5 percent ). Among the patients investigated, there was a statistically significant difference between pre-hysteroscopic diagnostic and hysteroscopy findings. There were also 76 females with normal hysterography and US, and 18 females with abnormal hysteroscopy results, resulting in an NPV of 86.8% for both ultrasonography and hysterography. Conclusion: hysteroscopy was the most precise diagnostic examination for lesions in comparison with ultra-sonography. The technique was of limited usage in the diagnosing of intra-uterine adhesions and some uterine deformities, while its global consequences in diagnosis of uterine deformities were better than those attained by ultrasonography.