Background: Obscure gastrointestinal bleeding (OGB) is defined as a gastrointestinal (GI) bleeding of unknown aetiology that persists despite conventional assessment. OGB accounts for about 5% of all GI bleeding and is a real issue for doctors. Objective: The major goal of this study was to see how effective capsule endoscopy (CE) was at diagnosing Egyptian patients with gastrointestinal (GI) bleeding, whether it was occult or overt. Patients and methods: This is a prospective observational single center study. 32 patients with OGIB (overt or occult) were referred for capsule endoscopy during the 30-month period (from June 2017 to December 2019) to the Endoscopy Unit at Hospital of Ain Shams University. Follow up patients after performing capsule endoscopy was done, some of them were recommended to do enteroscopy, and the others were referred for either surgery, radiological intervention or just medical treatment according to the pathology detected by the capsule. Results: In the current study, capsule endoscopy was able to detect accurate findings in all studied cases (twenty five) with exception of seven cases (22%) with overall diagnostic accuracy were 78% Conclusion: Capsule endoscopy is an excellent tool in evaluation of obscure gastrointestinal bleeding (both overt and occult) with relative safety and high diagnostic yield, which helps guiding therapeutic management.