Background: Models have been developed to predict a variety of outcomes, for all cardiac surgery and also for specific cardiac surgery procedures. The most broadly utilized model for anticipating mortality in cardiovascular surgery was EuroSCORE I, which has been upgraded in recent times to EuroSCORE II which was validated as a predictor for in-hospital mortality after cardiac surgery. Objective: The aim of the present study was to evaluate the accuracy of EuroSCORE II in prediction of mortality in Egyptian patients who would undergo valve surgery. Patients and methods: This retrospective cohort study evaluated the medical records of 180 adult patients who underwent valvular surgery in Departments of Cardiothoracic Surgery at Zagazig University Hospitals and Cardiac Surgery at National Heart Institute in Egypt, between January 2021 and July 2021. All studied patients were subjected to careful history taking, general examination, local cardiac examination, laboratory investigation, electrocardiogram, body mass index, and echocardiography. Results: The most common procedure done was mitral valve replacement representing (33.9%) followed by combined mitral valve replacement and tricuspid valve repair. The observed rate of in-hospital mortality was 7.8% (n = 14 patients). The real observed mortality rate was 4.4% of patients in 1^st quartile, 10.9% in 2^nd quartile, 14.6% of 3^rd quartile and 0.0% in 4^th quartile, with significant difference. Conclusion: The lower discriminative and predictive efficacy of EuroSCORE II in Egyptian patients undergoing mitral valve replacement might be explained by differences in clinical profile and the existence of additional local risk factors.