Background: ADHD (Attention Deficit/Hyperactivity Disorder) is the most frequent pediatric mental disorder. Zinc and iron are the most commonly investigated elements in children with ADHD. Objective: The aim of the current work was to discuss the role of iron and zinc in the brain development and the possible lowered serum levels of these elements in patients with ADHD to prevent and control some of ADHD symptoms. Patients and Methods: 42 children, aged from 4 to 14 years were included in this study as their parents complained from inattention, excess activity, or difficulties in school achievement of their children. All children included in the study were subjected to Full detailed medical history, clinical examination including physical examination, neurological examination, and laboratory investigations. Results: There was statistical significance decrease in both Fe and Zn among cases compare to control group. In addition, there were statistical significance increases in frequency of low Fe and Zn level among cases group compared to control group.  The levels of Fe and Zn had statistically significant –ve relationships with the ratings given by both parents and teachers. A statistically significant link between Zn and Fe levels was also found. There were statistical significance increase in frequency of ADHD C and PH and sever ADHD among cases had low Zn level compare to cases had normal level. Conclusion: It could be concluded that both zinc and iron serum levels were found to have a significant correlation with parent-reported hyperactivity symptoms, suggesting that patients with low levels of iron and zinc may be at greater risk of developing ADHD symptoms.