Background: Stone removal by endoscopic retrograde cholangiographic method (ERC) is a well-established procedure prior to laparoscopy cholecystectomy (LC) in patients with gall bladder stones (GBS). Objective: To compare the outcomes of early versus delayed LC after endoscopic common bile duct stones clearance in cases of combined GBS and CBDS. Patients and Methods: This comparative study included 28 patients who had undergone ERCP for CBDS and were then admitted for LC either early or delayed after ERCP from May 2020 to December 2020 at Zagazig University Hospitals. Patients had been divided into two groups: Group 1 (early group 14 patients) where LC was performed within 72 hrs after ERCP and Group 2 (delayed group 14 patients) where LC was performed after 6weeks from ERCP. Results: The mean operative time was shorter in the early group: 45.29 minutes (range: 29 - 60 minutes) than in the delayed group: 59.57 minutes (range: 40 - 92 minutes) which represented a significant difference in favor of the early group. As regards postoperative complications there was a statistically non-significant difference between both groups. Conclusion: an early LC after ERCP for the management of cholecystocholedecholithiasis is a safe, effective, and time-saving technique with a low rate of postoperative complications.