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231666

High Dose Versus Low Dose Oxytocin for Augmentation of Delayed Labour in Obese Women: A Randomized Clinical Trial

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Last updated: 03 Jan 2025

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Abstract

Buckhound: For augmentation of delayed labour, high- or low-dose oxytocin can be used, but the evidence for promoting high-dose in obese women is weak. In obese women, labour progress is often delayed, leading to a caesarean section despite labour augmentation with synthetic oxytocin. Objecitve: Our study aims to evaluate the effect of high dose oxytocin augmentation in spontaneously labouring obese women. Patients and methods: We included 202 patients who were randomly assigned to two groups in a randomized controlled trial (RCT) study. Patients were divided into two groups: Group I (low dose oxytocin) were given 2 mU/minutes (min) of oxytocin, which was gradually increased by 2 mU/min every 30 minutes until adequate uterine contractions were achieved. Patients in Group II (high dose oxytocin) were given 4 mU/min of oxytocin, which was gradually increased by 4 mU/min every 30 minutes until adequate uterine contractions were achieved. Results: Both management were equally effective in clinical data with no significant difference between the two studied groups (P>0.05).  Difference in oxytocin dose, duration of oxytocin, and uterine tachysystole between the two groups was statistically significant. The rates of caesarean section did not differ between groups (8.7% and 8.1%). The rates of instrumental vaginal births were similar. In terms of neonatal outcomes, there were no differences. Conclusion: Except for reducing labour duration, high dose oxytocin had no advantages over low dose oxytocin in labour augmentation. Low-dose oxytocin is less likely to cause uterine hyperstimulation, making it a safer option.  

DOI

10.21608/ejhm.2022.231666

Keywords

Caesarean section, obese women, oxytocin

Authors

First Name

Safwat Abdelrady

Last Name

Mohamed

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Affiliation

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City

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Orcid

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First Name

Ahmed Mohamed

Last Name

Abbas

MiddleName

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Affiliation

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Email

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City

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Orcid

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First Name

Esraa Gamal Abdelnaser

Last Name

Mostafa

MiddleName

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Affiliation

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Email

esraagamall77777@gmail.com

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Orcid

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Volume

87

Article Issue

1

Related Issue

31467

Issue Date

2022-04-01

Receive Date

2022-04-18

Publish Date

2022-04-01

Page Start

1,953

Page End

1,960

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_231666.html

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https://ejhm.journals.ekb.eg/service?article_code=231666

Order

159

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

High Dose Versus Low Dose Oxytocin for Augmentation of Delayed Labour in Obese Women: A Randomized Clinical Trial

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Article

Created At

22 Jan 2023