Background: Basic ultrasound measurement is not enough for proper assessment for the high-risk pregnancy like gestational diabetes mellitus and preeclampsia. Objective: This study aimed to add more parameters for evaluation of high-risk pregnancy including Doppler parameter and interventricular septal thickness, and their reflection on fetal outcome Patients and methods: 75 pregnant women were presented between 28-38 weeks gestation. They were divided into three groups: Group I included 25 pregnant diabetic women, group II included 25 pregnant women with gestational diabetes mellitus (GDM) and preeclampsia, and group III included 25 normal pregnant women as a control group (NC). Fetal hemodynamic indices were measured to all included groups and represented as the resistance index (RI), pulsatility index (PI) of umbilical artery (UA), middle cerebral artery (MCA), and interventricular septal (IVS) thickness. Results: The independent samples t-test showed that fetal weight, as well as the abdominal circumference (AC), was larger in GDM than in NC (P < 0.05) while were smaller in GDM with preeclampsia than in NC. Also, IVS thickness was larger in GDM than in NC (P < 0.05), while t-test showed that umbilical PI was higher in preeclampsia than in NC (P < 0.05) vice versa the MCA PI was lower in the preeclampsia than in NC (P < 0.05). Conclusion: Doppler indices especially MCA and umbilical PI as well as the interventricular septal thickness in late pregnancy were helpful in the diagnosis and assessment of high-risk pregnancy as well as their follow-up and in turn they could be considered as  an indicator of poor fetal outcome.