Background: Although most patients with chronic hepatitis C are asymptomatic, an appreciable number will experience symptoms that are due to liver disease and /or extrahepatic manifestations of HCV infection. Recognition of these symptoms will lead to early diagnosis and treatment of hepatitis C. Objective: This study aimed to assess the prevalence of extrahepatic manifestations in patients with chronic hepatitis c infection in Beni-Suef Governorate. Patients and methods: 200 patients with CHC are studied, their ages ranged between 20-60 years. They are collected randomly from Beni-Suef University and general hospitals and outpatient clinics. Results: There is a wide range of prevalence of EHMS of HCV infection, 8% were asymptomatic and accidentally discovered to have HCV. 92% of the total number of patients have at least one EHM. The commonest extrahepatic manifestations are rheumatological 51%, hematological 26%, fatigue 20%, dermatological 19%, neurological 16%, DM11%, cryoglobulinemia 9% and less common chest, renal, lymphoproliferative disorders, cardiac, thyroid dysfunction. Conclusion: Extrahepatic manifestations appear earlier than hepatic manifestations of HCV patients. Age and liver fibrosis are considered major risk factors of EHMs. Health professionals should be aware of these HCV-associated complications and presentations.