Background: The pathophysiology of AF is complex and multifactorial, involving ageing and a structural remodeling whereby apoptosis, inflammation and fibrosis are the hallmarks. Systemic inflammation is a strong predictor of atrial fibrillation. A key role for electrical remodeling is increasingly recognized, and experimental data suggest that inflammatory cytokines can directly affect connexins resulting in gap junction dysfunction. Objective: This study aimed to study epidemiology findings of paroxysmal atrial fibrillation. Patients and Methods: This case-control study was conducted on thirty-eight participants (19 males and 19 females). The included patients were recruited from Cardiology Department, Zagazig University Hospitals and Nasser Institute for Research and Treatment. Results: Regarding baseline characteristics, it was reported that mean age of AF group was 61.2 ± 9.1 years and control group was 58 ± 12 years with no statistical significant difference between the two studied groups. Most of AF patients were smokers and had hypertension. There were no statistical significant differences between the studied groups regarding hypertension, smoking status, sex and age. Regarding clinical presentation, it was observed that palpitation was more in AF group than in control group (78.9% and 10.6% respectively). Chest pain was more presented in AF group than in control group (36.8% vs 26.3% respectively), while dyspnea was more presented in AF group than in control group (47.4% vs 26.3% respectively).