Background: Although successful treatment of 5th metatarsal Jones fractures with intramedullary screw fixation is common, nonunion and refracture rates are not insignificant. Objective: This study aimed to monitor the management results of internal fixation of the base of the fifth metatarsal fracture of the foot by the intramedullary screw. Patients and Methods: At Zagazig University Hospitals, we performed a prospective study on 18 patients who had "jones fractures" in zone II at the base of their fifth metatarsal bone and who had all been treated with intramedullary screw fixation. Results: All the fractured patients had close isolated fractures 83.3% of them operated within the first 48 hours, only three patients needed more than 48 hours to be operated. The operation time in most of patients (77.8%) was less than one hour with mean 63.3 minutes. Most of patients (72.2%) achieved excellent, while the rest had good outcome according to AOFAS score at final follow up. Conclusion: It is safe and effective to use early screw fixation in the treatment of acute Jones fractures, which leads to a faster clinical union and a return to normal daily activities.