Background: The increased management of hemophilia has led to an increase in age-related problems in this population. These patients have high rates of cardiovascular risk factors, such as high blood pressure, hypercholesterolemia, and diabetes, which may have an impact on their overall health and healthcare costs. Objectives: To investigate hemophilia patients for lipid profile changes and its clinical impacts. Subjects and methods: this case-control study was conducted in Hematology Unit and Outpatients' Hematology Clinic of Pediatric Department at Zagazig University Hospitals over 6-month period. This study was conducted on 153 subject divided into 87 patients with clinical and laboratory diagnosis of hemophilia (65 hemophilia A and 22 hemophilia B) and 66 age and sex matched healthy children as a control group. All the studied groups were subjected to full medical history, thorough clinical examination and laboratory investigations such as complete lipid profile, fasting blood glucose and hemoglobin A1C. Results: Overweight was reported in 19.5% of hemophilia patients and obesity in 14.9%. High blood pressure, increase lipid profile (hypercholesterolemia, high LDL, hypertriglyceridemia) and high blood sugar were shown to be more significantly higher in the cases compared to the control group. Conclusion: Findings from our study revealed hyperlipidemia among people with hemophilia (PwH). Hyperlipidemia, being overweight or obese, and their implications must be prevented and managed early in healthcare for the hemophilia population if it is to improve overall health.