Background: HELLP occurs in 0.5%–0.9% of all pregnancies. About 30% of the cases happen within 48 hours after delivery. Women with postpartum HELLP syndrome have significantly higher incidences of complications. Because of the absence of classical signs of preeclampsia, it can confuse physicians and lead to delay in diagnosis. Therefore, it is associated with serious maternal and baby morbidity. Objective: We aimed in this review to highlight on HELLP syndrome after cesarean delivery due to its extreme risk to the mother and baby after birth. Methods: These databases were searched for articles published in English in 4 data bases: PubMed – Google scholar- The Egyptian knowledge bank and Science direct. Also, Boolean operators (AND, OR, NOT) had been used such as [HELLP Syndrome AND Caesarean section OR preeclampsia] and in peer-reviewed articles between March 1994 and August 2021. A 27-year date range was selected, no language limitations, and filtered in selected data basis for the last 27 years. Documents in a language apart from English have been excluded as sources for interpretation. Papers apart from main scientific studies had been excluded (documents unavailable as total written text, conversation, conference abstract papers and dissertations). Conclusion: The HELLP syndrome usually occurs with preeclampsia, so timely and early diagnosis of HELLP is important. Additionally, early treatment is important to prevent potentially fatal complications, especially in patients with poor health status.