Background: Poor postoperative pain management represents unpleasant experience which occurs in patients following surgical procedure. Recently, there have been increasing efforts to improve the perioperative pain management of children. Objective: To evaluate the paediatric postoperative pain management practice as well as identification of paediatric postoperative pain management influencing factors. Patients and methods: This cross-sectional study was conducted in Mansoura University Children Hospital, Mansoura University Emergency Hospital (ICU units). Each hospital serves a wide range of young patient's ages from one day up to 16 years old. All nurses who were involved in paediatric postoperative pain management were subjected to a specific questionnaire which assess different items that may affect the postoperative pain management practice. Results: Forty-seven participants have completed this study. The availability of pain assessment tool, level of knowledge, pain assessment, use comfort measures and considering pain management as a major priority were higher among the studied nursing staff. Meanwhile, participants who paid more attention for pain assessment and recording were lower. Good pain management practice was higher in female, married participants and among bachelor's, technical institute of nursing graduates and secondary nursing school graduated staff. The availability of pain assessment tool, morphine stock, knowledge, pain assessment, management and handover were associated with higher good pain practice among the studied nurse group. Conclusion: Nursing graduation level, marital status, knowledge, training and familiarity with pain assessment, and management tools, effective communication and pain management handover are fundamental factors that significantly improve the paediatric postoperative pain services.