Background: When warts appear on the skin, they can cause substantial pain and embarrassment since they are caused by human papillomavirus. Cryotherapy, laser vaporisation and surgical excision are some of the current techniques for treatment of skin cancer There are a number of ways to address these issues, but some of them are more invasive and may result in scarring. A huge number of warts makes local methods impractical for patients. Combining a targeted strategy with an increase of the host immune system has proven successful in treating various lesions. To evaluate the numerous vaccine antigens which was intralesionally injected for tratment of anogenital warts as well as , a comprehensive literature review was conducted. These non-specific intralesional immunotherapies include Candida albicans, mumps, and rubella; Trichophyton; and tuberculin antigens such as pure protein derivative, Mycobacterium w vaccine, and Bacillus Calmette-Guerin. Warts, particularly refractory and anogenital warts, can be treated safely, effectively, and comfortably using intralesional vaccine injection. Bivalent and guadrivalent HPV vaccines are currently available for primary prevention of HPV infection, which includes both types 16 and 18. There has been a dramatic reduction in the incidence of cervical neoplasia as well as genital warts due to HPV vaccines; however, they do not target genotypes that are specific to other skin locations. Objective: To evaluate the potential role of role of HPV vaccines in multiple recalcitrant warts treatment. Conclusion: Several previous studies have demonstrated that recent studies and case reports have shown promising efficacy of HPV vaccines in the treatment of warts. Keywords: