Background: Postpartum hemorrhage is the major cause of maternal mortality globally. So, the active management during the third stage of labor is recommended as a preventive measure. Active management includes measures that reduce duration and blood loss which occurs in this stage. The aim of this work was to compare between umbilical cord drainage, cord clamping and intraumbilical vein oxytocin injection in management of third stage of labour to reduce the incidence of postpartum hemorrhage and retained placenta. Patients and Methods: This is comparative clinical trial study which was conducted in Obstetrics and Gynecology Department – Zagazig University Hospitals and Zagazig General Hospital in the period from 1 January 2020 to 30 November 2020. Which included 90 women who were admitted at term pregnancy being in active phase of labour with Singleton pregnancy, Full term, no Medical disorders with pregnancy, and in whom fetal anomalies ruled out. Results: In this study we found that both group I and Ⅱ had statistically significant shorter third stage duration and less blood loss than patients of group Ⅲ. Mean ±SD was 7.73 ± 3.11 for group Ⅰ and 4.73 ± 1.8 for group Ⅱ and 9.9 ± 3.69 for group Ⅲ with highly significant difference P-value<0.001.The third stage of labor was significantly shorter in group 1 and 2 as compared to group 3. Conclusions. The use of intra umbilical vein injection of oxytocin and placental cord drainage significantly reduced the duration of the third stage of labor and blood loss.