Background: Diabetic peripheral neuropathy (DPN) considered a potential complication correlated with diabetes type 1 and type 2 (T2DM). Objective: The present study was aimed for better control of T2DM complications such as diabetic DPN and to assess the relationship between serum uric acid (SUA) level and DPN. Patients and Methods: This cross-sectional study was carried out in Internal Medicine Outpatient Clinics, Zagazig University Hospital and El Ahrar Teaching Hospital. The study included 50 patients; aged between 42 and 78 years, divided into two groups, diabetic group without neuropathy (DM) and diabetic group with peripheral neuropathy. Results: The findings revealed that there was a statistically insignificant difference between DM, and DPN groups and gender, age, weight, height, BMI. There was a significant difference between the two studied groups and duration of diabetes and SUA. There was a statistically insignificant difference between DM and DPN groups and type of medication, systolic BP, diastolic BP, Hemoglobin A1c, and fasting blood glucose. Conclusion: It could be concluded that elevated SUA level increased the chance of developing peripheral neuropathy in a person with type 2 diabetes (T2DM). Many animal experiments and large-scale clinical observations and experiments are needed to confirm this observation.