Background: Weaning from mechanical ventilation can be defined as the process of abruptly or gradually withdrawing ventilatory support.  Recommendations for weaning practice would be based on the findings of multiple well-designed randomized trials conducted over the past decade. In comparison to more progressive removal of ventilatory aid, quick extubation following successful spontaneous breathing trials expedites weaning and minimizes the time of mechanical ventilation (MV). More recently, pressure support ventilation and bi-level positive airway pressure modes have become available. Modern ventilators are increasingly sensitive, allowing easy patient triggering of supported breaths, modes such as tube compensation, and measurement of numerous respiratory parameters. Developments in weaning techniques have paralleled these improvements in ventilator functionality. Objective: In this review article, the initially required criteria to start and the weaning methods from mechanical ventilation. Methods: These databases were searched for articles published in English in 3 databases [PubMed – Google scholar- science direct] and Boolean operators (AND, OR, NOT) had been used such as [Weaning AND Mechanical Ventilation OR Intensive Care Unit] and in peer-reviewed articles between 1992 and 2021. Documents in a language apart from English have been excluded as sources for interpretation were not found. Papers apart from main scientific studies had been excluded: documents unavailable as total written text, conversation, conference abstract papers, and dissertations. Conclusion: All cases that received ventilatory assistance should be evaluated daily for weaning suitability. This may include satisfying several preconditions and then undergoing an SBT. If weaning is ineffective, either PSV or daily spontaneous breathing spells of increasing length should be tried.