219974

Evaluation of The Diagnostic Value of Brain Natriuretic Peptide for Detection of Left Ventricular Systolic Dysfunction and Pulmonary Hypertension in Patients with Acute Exacerbat

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Last updated: 03 Jan 2025

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Abstract

Background: One of the most critical health concerns of our day is acute deterioration of chronic obstructive lung disease (COPD). Detecting concurrent heart illness in these individuals might be challenging. Objective: Aims of this study were determining the diagnostic value of B-type natriuretic peptide (BNP) levels in the identification of acute COPD exacerbations (AECOPD) that were linked with left ventricular (LV) dysfunction and pulmonary hypertension. Methods: a prospective study of 100 patients with acute COPD exacerbations was done. All research participants were subjected to history taking, clinical examination, laboratory testing, blood gas analysis, echocardiography, and NT-pro BNP plasma level estimation. Results: Receiver operating characteristic (ROC) curve for BNP as a diagnostic for LV systolic dysfunction showed that area under the curve (AUC) was 0.923 at cut off point of 72.1 ng/ml with sensitivity of 93.3% and specificity of 84.6% (P<0.001).   Conclusion: Heart failure is confirmed when the average natriuretic (NT)-BNP level in the left ventricle during AECOPD is higher than normal, which should prompt quick treatment for both conditions.  

DOI

10.21608/ejhm.2022.219974

Keywords

Acute exacerbation of COPD, Brain natriuretic peptide, Cardiac dysfunction, pulmonary hypertension

Authors

First Name

Hamdy

Last Name

Abdel Azeem

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First Name

Mohamed S.

Last Name

Zaghlol

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Email

zaghlol_msz@yahoo.com

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Orcid

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First Name

Ahmed

Last Name

Lotfi

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Volume

86

Article Issue

1

Related Issue

29518

Issue Date

2022-01-01

Receive Date

2022-02-16

Publish Date

2022-01-01

Page Start

968

Page End

972

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_219974.html

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https://ejhm.journals.ekb.eg/service?article_code=219974

Order

157

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Evaluation of The Diagnostic Value of Brain Natriuretic Peptide for Detection of Left Ventricular Systolic Dysfunction and Pulmonary Hypertension in Patients with Acute Exacerbat

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Article

Created At

22 Jan 2023