Background: Bronchial asthma is one of the relevant diseases of the respiratory tract, the asthma is one of the forms of respiratory allergy. The change in environment and aeroallergens are the main etiology of asthma. Allergy of asthma is thought to affect the bronchial region of the respiratory airway.  Objective: The current study aimed to compare the total IgE elevation and skin prick test (SPT) positivity to evaluate the IgE and SPT ability to assess the asthmatic severity. Subjects and Methods: This retrospective case study was carried out on 3450 cases at the outpatient clinic and Chest Department at Zagazig University and did skin prick test and IgE in authorized centers were collected from 2015 -2019. The cases were already diagnosed asthmatic according to Global Initiative for Asthma (GINA) ⁽⁹⁾ guidelines and were divided according to severity into mild, moderate, and severe according to GINA guidelines. Results: IgE has been tested for different aeroallergens and has strong significant elevation with (P< 0.001) in Alternaria, cat hair, cotton, birch, and helminths aeroallergen. Most of the cases with elevated IgE had moderate asthma severity followed by mild severity cases then severe cases. Conclusion: Comparing the results of SPT and IgE, the SPT test is more accurate, reliable, and easy in detecting the aeroallergen sensitivity.