215204

Diagnostics and Outcome Predictorso Drug Induced Liver Injury: A Single Center Prospective Study

Article

Last updated: 03 Jan 2025

Subjects

-

Tags

-

Abstract

Background: Although drug-induced liver injury (DILI) is a rare clinical event, it carries significant morbidity and mortality. The diagnostic approach of DILI is still challenging because of lack of reliable markers that would allow distinguishing DILI from other causes of liver injury. Objective: To study the demographic, clinical and laboratory characteristics, and their relation to outcome of patients with DILI. Patients and Methods: Case control study conducted on 80 participants divided into two groups; Group I 40 patients with acute DILI and Group II 40 patients with acute viral induced liver injury. Subjects were systematically evaluated for clinical and laboratory characteristics, other etiologies, severity of DILI with application of Roussel Uclaf Causality Assessment Method (RUCAM) and liver biopsy whenever feasible and were all followed for 6 months thereafter. Results: Diclofenac was the most incriminated drug in DILI group (16 cases, 40%). Hepatocellular injury pattern was more common (28 cases, 70%). Infection with acute hepatitis B virus (HBV) and hepatitis A virus (HAV) were the commonest etiology of viral hepatitis (32 cases, 80%). All patients with acute viral hepatitis, improved with no recorded mortality nor chronicity. While 6 patients (15%) with DILI died. Conclusion:  The diagnostic approach of DILI is still rudimentary and inaccurate and require high index of suspicion and thus, careful assessment is required to distinguish DILI from other causes of liver injury.  

DOI

10.21608/ejhm.2022.215204

Keywords

Diclofenac, Drug-induced liver injury, hepatocellular, viral hepatitis

Authors

First Name

Omkolsoum M.

Last Name

Alhaddad

MiddleName

-

Affiliation

-

Email

dromkolsoum@yahoo.com

City

-

Orcid

-

First Name

Amany S.

Last Name

ElSharkawy

MiddleName

-

Affiliation

-

Email

-

City

-

Orcid

-

First Name

Olfat M.

Last Name

Hendy

MiddleName

-

Affiliation

-

Email

-

City

-

Orcid

-

First Name

Maha M.

Last Name

Elsabaawy

MiddleName

-

Affiliation

-

Email

-

City

-

Orcid

-

First Name

Mohamed A.

Last Name

Mazaly

MiddleName

-

Affiliation

-

Email

-

City

-

Orcid

-

First Name

Aliaa A.

Last Name

Sabry

MiddleName

-

Affiliation

-

Email

-

City

-

Orcid

-

Volume

86

Article Issue

1

Related Issue

29518

Issue Date

2022-01-01

Receive Date

2022-01-21

Publish Date

2022-01-01

Page Start

653

Page End

659

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_215204.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=215204

Order

105

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Diagnostics and Outcome Predictorso Drug Induced Liver Injury: A Single Center Prospective Study

Details

Type

Article

Created At

22 Jan 2023