Background: Egyptian women value contraceptive methods for their effectiveness against pregnancy. Objective: This study aimed to determine the usage and side effects of oral contraceptive pills among the target group. Patients and methods: A cross-sectional study was carried out on 350 women from family health centers and units in Abo Hammad District, Sharkia Governorate. Data were collected through a questionnaire Results: Majority (81.1%) of the studied group used combined pills The most frequent side effects found among them were depression, breast pain & inflammation, weight gain and abnormal vaginal secretions (63.7%, 57.7%, 56.6% & 56.3% respectively). Conclusion The present study revealed that prevalence of pills usage among 350 studied females in Abo Hammad District, Sharkia Governorate was 62.9%. The prevalence of combined pills was 81.1% and Mini pills was 18.9%.