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211049

Could Cardiac MR Imaging with Late Gadolinium Enhancement Affect The Risk Stratification and Outcome Prediction In Non-Ischemic Cardiomyopathies?

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Last updated: 03 Jan 2025

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Abstract

Background: Cardiac MR (CMR) evaluatingnon-ischemic cardiomyopathies (NICMs) is superior 3D imaging with non-invasiveness, more accuracy and reproducibility of measurements. It provides comprehensive structural, functional information, tissue characterization, and assesses fibrosis by LGE. Objective: The study aimed to investigate these imaging data and their prognostic value in NICM. Patients and methods: 46 NICM patients were assessed by echocardiography/cardiac magnetic resonance (CMR). They were divided into 3 groups: dilated, hypertrophic and miscellaneous types. Late gadolinium enhancement (LGE) presence and myocardial extent/percentage were assessed with clinical follow up for a median of 1-year for any Major adverse cardiac events (MACE). For each group, univariate analysis of clinical/imaging risk factors in the associations with LGE/MACE was performed.  Results: Twenty-six dilated cardiomyopathypatients, 62% had LGE and 31% had MACE. Using LGE as a predictor for MACE was statistically significant (p = 0.007). Using univariate analysis, the presence of LGE (p=0.00) and the extent of LGE (p < 0.0001) demonstrated the strongest unadjusted association with MACE. ROC curves revealed a cutoff value of LGE > 4.5% as MACE predictor. Twelve hypertrophic cardiomyopathypatients (67%) had LGE and (50%) had MACE. Using LGE as a predictor for MACE was statistically significant (p=0.014). Using univariate analysis, the presence of LGE (p=0.01) and the extent of LGE (p=0.01) demonstrated the strongest unadjusted association with MACE. ROC curves revealed a cutoff value of LGE > 4.5% as MACE predictor. Conclusion: CMR with LGE is crucial in NICM evaluation with prognostic value; changing the way that myocardial disorders will be understood and managed in the near future.    

DOI

10.21608/ejhm.2022.211049

Keywords

NICM, CMR, LGE

Authors

First Name

Reham

Last Name

Sameeh

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Email

reham.sameeh@aun.edu.eg

City

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Orcid

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First Name

Samy Abd Elaziz

Last Name

Sayed

MiddleName

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Affiliation

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Email

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Orcid

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First Name

Mostafa Hashem Mahmoud

Last Name

Othman

MiddleName

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Affiliation

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Email

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City

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Orcid

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First Name

Ahmed Ali

Last Name

Obeidalla

MiddleName

-

Affiliation

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Email

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City

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Orcid

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First Name

Marwa

Last Name

Samy

MiddleName

-

Affiliation

-

Email

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-

Orcid

-

Volume

86

Article Issue

1

Related Issue

29518

Issue Date

2022-01-01

Receive Date

2021-12-28

Publish Date

2022-01-01

Page Start

199

Page End

210

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_211049.html

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https://ejhm.journals.ekb.eg/service?article_code=211049

Order

33

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Could Cardiac MR Imaging with Late Gadolinium Enhancement Affect The Risk Stratification and Outcome Prediction In Non-Ischemic Cardiomyopathies?

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Article

Created At

22 Jan 2023